KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SLC6A4
All Species:
23.03
Human Site:
T616
Identified Species:
46.06
UniProt:
P31645
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P31645
NP_001036.1
630
70325
T616
I
K
S
I
T
P
E
T
P
T
E
I
P
C
G
Chimpanzee
Pan troglodytes
XP_001135066
630
70262
T616
I
K
S
I
T
P
E
T
P
T
E
I
P
C
G
Rhesus Macaque
Macaca mulatta
Q9MYX0
630
70239
T616
I
K
S
I
T
P
E
T
P
T
E
I
P
C
G
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q60857
630
70129
T616
I
K
S
I
T
P
E
T
P
T
E
I
P
C
G
Rat
Rattus norvegicus
P31652
630
70153
T616
I
K
S
I
T
P
E
T
P
T
E
I
P
C
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508462
865
94609
N844
A
Y
C
L
T
P
E
N
E
H
H
L
V
A
Q
Chicken
Gallus gallus
NP_998737
670
74409
T656
L
K
S
I
T
P
E
T
A
T
E
I
P
F
G
Frog
Xenopus laevis
A7Y2W8
633
71004
G621
D
L
S
L
T
I
Q
G
S
N
G
Q
A
H
T
Zebra Danio
Brachydanio rerio
NP_001035061
646
72103
A629
L
K
G
I
T
P
E
A
P
G
S
S
G
P
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P51905
622
69307
E607
L
Q
E
S
F
Q
P
E
D
N
C
G
S
V
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q03614
615
69247
T606
T
E
Y
I
P
I
P
T
T
Q
P
H
S
D
I
Sea Urchin
Strong. purpuratus
XP_001204030
641
70931
Q624
F
V
A
I
T
S
P
Q
E
H
P
D
H
K
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
98.5
N.A.
N.A.
92.8
91.7
N.A.
38.1
77.6
42.1
68.5
N.A.
50.4
N.A.
43.6
49.4
Protein Similarity:
100
99.5
99.5
N.A.
N.A.
95.5
94.9
N.A.
52.9
85.2
60.8
80.6
N.A.
66.9
N.A.
63.3
66.6
P-Site Identity:
100
100
100
N.A.
N.A.
100
100
N.A.
20
80
13.3
40
N.A.
0
N.A.
13.3
13.3
P-Site Similarity:
100
100
100
N.A.
N.A.
100
100
N.A.
33.3
86.6
26.6
46.6
N.A.
13.3
N.A.
20
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
9
0
0
0
0
9
9
0
0
0
9
9
0
% A
% Cys:
0
0
9
0
0
0
0
0
0
0
9
0
0
42
0
% C
% Asp:
9
0
0
0
0
0
0
0
9
0
0
9
0
9
0
% D
% Glu:
0
9
9
0
0
0
67
9
17
0
50
0
0
0
0
% E
% Phe:
9
0
0
0
9
0
0
0
0
0
0
0
0
9
0
% F
% Gly:
0
0
9
0
0
0
0
9
0
9
9
9
9
0
50
% G
% His:
0
0
0
0
0
0
0
0
0
17
9
9
9
9
0
% H
% Ile:
42
0
0
75
0
17
0
0
0
0
0
50
0
0
9
% I
% Lys:
0
59
0
0
0
0
0
0
0
0
0
0
0
9
0
% K
% Leu:
25
9
0
17
0
0
0
0
0
0
0
9
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
9
0
17
0
0
0
0
0
% N
% Pro:
0
0
0
0
9
67
25
0
50
0
17
0
50
9
0
% P
% Gln:
0
9
0
0
0
9
9
9
0
9
0
9
0
0
17
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
59
9
0
9
0
0
9
0
9
9
17
0
0
% S
% Thr:
9
0
0
0
84
0
0
59
9
50
0
0
0
0
17
% T
% Val:
0
9
0
0
0
0
0
0
0
0
0
0
9
9
9
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
9
9
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _